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Survival Outcomes in Early Stage Laryngeal Cancer
Uchechukwu C Megwalu1, Haig Panossian2
1Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, U.S.A. megwaluu@yahoo.com.
Aim:
To evaluate survival outcomes of radiotherapy versus surgical resection in the treatment of early stage laryngeal cancer.
Patients And Methods:
Data was extracted from the Surveillance, Epidemiology, and End Results 18 Database. The cohort included 5,301 patients diagnosed with stages I and II laryngeal squamous cell carcinoma between 1992 and 2009, treated with either surgical therapy or radiotherapy.
Results:
Patients who received surgical therapy had better overall survival (OS) than patients who received radiation therapy (p<0.001). The difference in OS between treatment groups remained after stratification by stage (p<0.001 for Stage I; p=0.03 for Stage II) and subsite (p<0.001). On multivariable analysis, the radiotherapy group had worse OS (hazard ratio (HR)=1.29).
Conclusion:
Patients with early-stage laryngeal cancer treated with surgical therapy have better survival outcomes than patients treated with non-surgical therapy.
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