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Systemic Inflammatory Response After Open, Laparoscopic and Robotic Surgery in Endometrial Cancer Patients
Radovan Pilka1, Radim Marek2, Tomas Adam3
1Department of Obstetrics and Gynecology, Medical Faculty Palacký University and Faculty Hospital, Olomouc, Czech Republic radovan.pilka@fnol.cz.
Aim:
To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients.
Materials And Methods:
A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively.
Results:
The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups.
Conclusion:
The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma.
