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Initial Results of Hypofractionated Carbon Ion Radiotherapy for Cholangiocarcinoma
Takanori Abe1, Kei Shibuya2, Yoshinori Koyama3
1Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi, Japan mrtaka100@yahoo.co.jp.
Aim:
To report initial results of hypofractionated carbon ion radiotherapy (C-ion RT) for cholangiocarcinoma.
Patients And Methods:
Data regarding seven patients with cholangiocarcinoma treated by C-ion RT were analyzed. Prescribed doses were 52.8 Gy [relative biological effectiveness (RBE)] or 60.0 Gy (RBE) in four fractions for intrahepatic cases and 12 fractions for hilar hepatic/close to gastro-intestinal tract cases. Local control and overall survival were evaluated and toxicity was graded using Common Terminology Criteria for Adverse Events, version 4.0.
Results:
The median follow-up period was 16 months. There were two patients with stage I cancer, one with stage II, one with stage III, and three with stage IVA. Local control was achieved in five out of seven patients (71%) and survival was maintained in six out of seven patients (86%). There were no occurrences of acute or late toxicity of grade 3 or higher.
Conclusion:
Initial results show that hypofractionated C-ion RT appears to be tolerated and effective for cholangiocarcinoma.
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