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Chronic subdural hematomas in Finnish patients with Huntington's disease
Jussi O T Sipilä1,2,3, Jussi P Posti4,5,6, Kari Majamaa7,8
1Division of Clinical Neurosciences, Department of Neurology, Turku University Hospital, Turku, Finland. jussi.sipila@utu.fi.
Background:
Many features of Huntington's disease (HD) make these patients susceptible to subdural hematomas (SDH), but there are no previous reports on the epidemiology of SDH in this population. We investigated the incidence and risk factors of chronic SDH.
Methods:
A national cohort of 192 Finnish patients with HD was investigated. Information was gathered from medical records and administrative registries.
Results:
The incidence rate of SDH was 68.3/100,000 person-years among the 192 patients. Seven patients were identified with a chronic SDH at or after the diagnosis of HD. Their age was 58.5 ± 15.0 years (mean ± SD) at the time of diagnosis of HD and 60.9 ± 14.1 years at the time of diagnosis of SDH. The incidence rate of chronic SDH after the diagnosis of HD was 4.7/1000 person-years and by 8.3 years of follow-up the cumulative risk was 5.4 %. Review of the patient charts revealed only a few of the common risk factors for chronic SDH, but the rate of reoperations was high.
Conclusions:
The incidence of chronic SDH was higher in patients with HD than that in the general population. Incidence of chronic SDH began to increase at the time of expected motor onset of HD. Common risk factors of SDH were scarce aside from fall-related head injuries.
