Experimental study in pulmonary artery sealing with a vessel-sealing device

Area of Science:

• Thoracic Surgery
• Surgical Devices
• Vascular Surgery

Background:

• Video-assisted thoracoscopic surgery (VATS) safety can be improved with advanced vessel-sealing devices.
• The Enseal tissue-sealing device was evaluated for its efficacy in sealing pulmonary arteries.

Purpose of the Study:

• To assess the feasibility and safety of using the Enseal device for pulmonary artery sealing.
• To evaluate the acute pressure tolerance and chronic durability of Enseal-sealed pulmonary arteries.

Main Methods:

• Pulmonary arteries from beagle dogs were sealed using Enseal, ligation, or combined methods.
• Acute pressure tolerance was tested up to 75 mm Hg.
• Chronic-phase durability was assessed in a survival model following left lower lobectomy.

Main Results:

• All Enseal-sealed pulmonary artery sections (n=91) demonstrated pressure tolerance exceeding 75 mm Hg.
• No sealing failures occurred in the acute or chronic phases.
• Pathological examination revealed healing and persistent hemostasis at sealed sites after 2 and 4 weeks.

Conclusions:

• Enseal device sealing of pulmonary arteries is feasible and safe in acute settings, withstanding pressures >75 mm Hg.
• The device ensures persistent hemostasis, indicating safety and efficacy for chronic use.
• Enseal device application is a viable option for pulmonary artery sealing in thoracic surgery.