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Risk Factors for Thrombosis, Overshunting and Death in Infants after Modified Blalock-Taussig Shunt

Mehmet Küçük1, Rahmi Özdemir1, Mustafa Karaçelik2

  • 1Department of Pediatric Cardiology;

Acta Cardiologica Sinica
|June 9, 2016
PubMed

Insights

A Modified Blalock-Taussig shunt (MBTS) may improve lung blood flow in infants with congenital heart defects. A low preoperative partial thromboplastin time (aPTT) may indicate a higher risk of thrombosis after MBTS surgery.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Surgery
  • Neonatal Intensive Care

Background:

  • The Modified Blalock-Taussig shunt (MBTS) procedure is crucial for managing certain congenital heart defects in infants.
  • This study focuses on risk factors for thrombosis, overshunting, and mortality following MBTS in young children.

Purpose of the Study:

  • To evaluate risk factors associated with the Modified Blalock-Taussig shunt (MBTS) procedure.
  • To identify predictors of thrombosis, overshunting, and death in infants undergoing MBTS.

Main Methods:

  • Retrospective analysis of 44 infants under 2 years who underwent MBTS between 2009-2013.
  • Assessment of preoperative characteristics including hemoglobin, hematocrit, and coagulation parameters (PTT).
  • Investigation of post-operative outcomes such as thrombosis, overcirculation, and mortality.

Main Results:

  • 8 out of 44 patients died post-surgery; 4 patients (9.1%) experienced shunt thrombosis.
  • Lower partial thromboplastin time (aPTT) was significantly associated with thrombosis (28.7s vs 35s, p=0.04).
  • Overshunting occurred in 5 patients, with a higher shunt size/body weight ratio (1.25 vs 1.06).

Conclusions:

  • Assessing risk factors for the MBTS operation is vital for patient outcomes.
  • Preoperative low aPTT may serve as a predictive indicator for thrombosis in infants following MBTS surgery.
  • Further research is warranted to refine risk stratification and improve surgical outcomes.
Abstract

Keywords:
Activated partial thromboplastin timeRisk factorsShunt thrombosis

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