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Updated: Mar 19, 2026
Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
Published on: January 27, 2018
Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth
Yuki Takabayashi1, Masaki Nambu1, Masayuki Ishihara2
1Department of Plastic and Reconstructive Surgery, Research Institute, National Defense Medical College, Tokorozawa, Saitama, Japan.
Purpose:
Although treatments for alopecia are in high demand, not all treatments are safe and reliable. Dalteparin/protamine nanoparticles (D/P NPs) can effectively carry growth factors (GFs) such as fibroblast GF (FGF)-2. The purpose of this study was to identify the effects of FGF-2-containing D/P NPs (FGF-2&D/P NPs) on hair growth.
Patients And Methods:
In this study, the participants were 12 volunteers with thin hair. One milliliter of FGF-2 (100 ng/mL) and D/P NPs (56 μg/mL) was applied and massaged on the skin of the scalp by the participants twice a day. They were evaluated for 6 months. Participants were photographed using a digital camera for general observation and a hair diagnosis system for measuring hair diameter.
Results:
The mean diameter of the hairs was significantly higher following the application of FGF-2&D/P NPs for 6 months. Objective improvements in thin hair were observed in two cases. Nine participants experienced greater bounce and hair resilience.
Conclusion:
The transdermal application of FGF-2&D/P NPs to the scalp can be used as a new treatment for alopecia.
