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Cefepime-induced encephalopathy with normal renal function.
Andrew Meillier1, David Rahimian1
1Department of Medicine , Temple University Hospital , Philadelphia, PA , USA.
Oxford Medical Case Reports
|June 9, 2016
Summary
Cefepime, a fourth-generation cephalosporin, can cause neurological adverse effects like encephalopathy. This case highlights cefepime-induced encephalopathy in a patient with normal renal function, resolving after medication cessation.
Area of Science:
- Neuroscience
- Pharmacology
- Infectious Diseases
Background:
- Cefepime is a broad-spectrum, fourth-generation cephalosporin antibiotic.
- It is widely prescribed for various bacterial infections.
- Neurological adverse effects, including seizures and encephalopathy, have been associated with cefepime, particularly in patients with renal impairment.
Observation:
- This report details a case of a patient experiencing cefepime-induced encephalopathy.
- Notably, the patient presented with normal renal function.
- Symptoms fully resolved upon discontinuation of cefepime therapy.
Findings:
- Cefepime can induce neurological toxicity, such as encephalopathy, even in patients with preserved renal function.
- This suggests that factors beyond renal dose adjustment may influence cefepime neurotoxicity.
- Prompt recognition and cessation of the antibiotic are crucial for symptom reversal.
Implications:
- Clinicians should maintain a high index of suspicion for cefepime-induced neurotoxicity, irrespective of renal status.
- Further research into the mechanisms of cefepime neurotoxicity is warranted.
- This case underscores the importance of vigilant monitoring for adverse drug reactions during antibiotic therapy.
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