Related Experiment Video
Updated: Mar 19, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Determinants of Mortality in Patients with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention
Alexandros Papachristidis1, Wei Yao Lim2, Christos Voukalis1
1Department of Cardiology, King's College London, London, UK.
Insights
Mortality in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) rises with age, advanced CKD stage, and reduced left ventricular function. Acute coronary syndromes also predict higher mortality compared to stable coronary artery disease.
Area of Science:
- Cardiology
- Nephrology
- Clinical Medicine
Background:
- Renal impairment is a significant predictor of mortality in general and cardiac populations.
- Understanding mortality factors in chronic kidney disease (CKD) patients undergoing percutaneous coronary intervention (PCI) is crucial.
Purpose of the Study:
- To evaluate factors determining mortality in CKD patients after PCI.
- To identify key predictors of all-cause mortality in this high-risk cohort.
Main Methods:
- A consecutive series of 293 CKD patients undergoing PCI between January 2007 and September 2012 were analyzed.
- All-cause mortality was assessed during a follow-up period of 12-69 months (mean 38.8 ± 21.7 months).
Main Results:
- Age, PCI indication, CKD stage, and left ventricular ejection fraction were significantly associated with mortality.
- CKD stage 5 (HR = 6.39) and severely impaired left ventricular function (HR = 4.04) were the strongest predictors.
- Factors such as gender, hypertension, diabetes, and intervention details did not correlate with mortality.
Conclusions:
- Mortality in CKD patients undergoing PCI escalates with increasing age, worsening CKD stage, and declining left ventricular systolic function.
- Patients with acute coronary syndromes face higher mortality post-PCI than those with stable coronary artery disease.
Background:
Renal impairment is a known predictor of mortality in both the general population and in patients with cardiac disease. The aim of this study was to evaluate factors that determine mortality in patients with chronic kidney disease (CKD) who have undergone percutaneous coronary intervention (PCI).
Methods:
In this study we included 293 consecutive patients with CKD who underwent PCI between 1st January 2007 and 30th September 2012. The primary outcome that we studied was all-cause mortality in a follow-up period of 12-69 months (mean 38.8 ± 21.7).
Results:
Age (p < 0.001), PCI indication (p = 0.035), CKD stage (p < 0.001) and left ventricular ejection fraction (p < 0.001) were significantly related to mortality. CKD stage 5 [hazard ratio (HR) = 6.39, 95% CI: 1.51-27.12) and severely impaired left ventricular function (HR = 4.04, 95% CI: 2.15-7.59) were the strongest predictors of mortality. Other factors tested (gender, hypertension, diabetes, hyperlipidaemia, established peripheral vascular disease/stroke, coronary arteries intervened, number of vessels treated, number of stents implanted and length of lesion treated) did not show any correlation with mortality.
Conclusions:
The mortality of patients with CKD undergoing PCI increases with age, worsening CKD stage and deteriorating left ventricular systolic function, and it is also higher in patients with acute coronary syndromes compared to those with stable coronary artery disease.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Related Concept Videos
01:28Cardiac Catheterization I: Pre-Procedure Overview
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:28Chronic Kidney Disease III: Interprofessional Care
01:28Kidney Transplant I: Introduction
01:25Chronic Kidney Disease I: Introduction
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...