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Published on: December 3, 2020
Prediction of Gut Wall Integrity Loss in Viral Gastroenteritis by Non-Invasive Marker
Hala G Elnady1, Lobna S Sherif1, Maysa T Saleh1
1Child Health Department, National Research Centre, Cairo, Egypt.
Background:
Intestinal fatty acid binding proteins (I-FABPs) are mainly expressed in the intestinal villi, which are the initial site of destruction in viral gastroenteritis.
Aim:
This study was designed to assess serum I-FABPs as a predictor of gut wall integrity loss in viral gastroenteritis.
Patients And Methods:
This case-control cross-sectional study was conducted on 93 cases of acute viral gastroenteritis. Twenty-eight healthy children matching in age were recruited as control group. Serum I-FABPs were measured using ELISA technique. Viral detection and typing were done by PCR for adenovirus, and by Reverse transcriptase PCR for rotavirus, astrovirus and norovirus.
Results:
Serum I-FABPs level was significantly higher in the cases compared to the controls and was also higher in the 46 rotavirus gastroenteritis cases compared to other viral gastroenteritis cases. Serum I- FABPs level was significantly higher in severely dehydrated cases as compared to mildly dehydrated ones (P=0.037).
Conclusion:
Serum I-FABPs could be used as an early and sensitive predictor marker of gut wall integrity loss in children with viral gastroenteritis and its level can indicate case severity.
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