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Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin

Soha M Abd El Dayem1, Ahmed A Battah2, Amal El Shehaby3

  • 1Pediatrics Department, National Research Centre, Cairo, Egypt.

Open Access Macedonian Journal of Medical Sciences
|June 9, 2016
PubMed

Insights

Omentin levels are lower and oxidized LDL is higher in type 1 diabetes patients, impacting cardiac and renal function. These findings suggest Omentin

Area of Science:

  • Endocrinology
  • Cardiology
  • Nephrology

Background:

  • Type 1 diabetes (T1D) is associated with increased cardiovascular and renal complications.
  • Omentin, an adipokine, has shown potential roles in metabolic and cardiovascular health.
  • Oxidized low-density lipoprotein (OxLDL) is implicated in atherosclerosis and diabetic complications.

Purpose of the Study:

  • To investigate the relationship between Omentin levels and cardiac affection in individuals with T1D.
  • To explore the association of Omentin with cardiac autonomic neuropathy and renal function markers in T1D.

Main Methods:

  • Cross-sectional study including 62 T1D patients and 30 controls.
  • Assessed serum Omentin, OxLDL, HbA1c, lipid profile, and urinary albumin/creatinine ratio.
  • Utilized 24-hour Holter monitoring and statistical analyses including regression.

Main Results:

  • Diabetic patients exhibited significantly lower Omentin and higher OxLDL compared to controls.
  • Cardiac autonomic function parameters (e.g., RMSSD, ST deviation) were significantly altered in T1D.
  • Omentin levels were significantly correlated with Holter parameters and OxLDL, and also with renal markers.

Conclusions:

  • T1D patients demonstrate cardiac autonomic neuropathy and altered Omentin/OxLDL profiles.
  • Reduced Omentin and elevated OxLDL may influence glucose metabolism and contribute to cardiac and renal complications in T1D.
  • Omentin appears to play a role in cardiac affection and renal health in the context of T1D.
Abstract

Keywords:
24 hr holterCardiovascularautonomic neuropathycoronary calcificationtype 1 diabetic patient

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