Related Experiment Video
Updated: Mar 19, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
Published on: October 10, 2011
STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC
Sarani Ghoshal1, Bryan C Fuchs1, Kenneth K Tanabe1
1Division of Surgical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
Cancer stem cell (CSC) marker CD133 was found to be upregulated in many cancers including hepatocellular carcinoma (HCC). However, the molecular mechanism of CD133 regulation in the liver tumor microenvironment has remained elusive. In this study Won and colleagues report that interleukin-6 (IL-6) mediated signal transducer and activator of transcription factor 3 (STAT3) signaling and hypoxia enhance the expression of CD133 and promote the progression of HCC.
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Regulation of Angiogenesis and Blood Supply

