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Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology

Reza Golestani1,2, Jae-Joon Jung3,4, Mehran M Sadeghi5,6

  • 1Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT 06511, USA. reza.golestani@yale.edu.

Journal of Clinical Medicine
|June 9, 2016
PubMed

Insights

Molecular imaging detects key molecules in cardiovascular diseases like atherosclerosis. Nuclear imaging techniques show promise for early diagnosis and patient selection in vascular remodeling research.

Area of Science:

  • Cardiovascular Research
  • Molecular Imaging
  • Vascular Biology

Background:

  • Angiogenesis and vascular remodeling are central to cardiovascular diseases, including myocardial ischemia, peripheral arterial disease, atherosclerosis, and aortic aneurysm.
  • Detecting molecular and cellular players (e.g., vascular endothelial growth factor, αvβ3 integrin, matrix metalloproteinases) is crucial for understanding these conditions.

Purpose of the Study:

  • To review the state-of-the-art molecular imaging techniques for angiogenesis and vascular remodeling.
  • To highlight the potential of nuclear imaging (PET and SPECT) for clinical translation in cardiovascular disease research.

Main Methods:

  • Evaluation of molecular imaging techniques in animal models of angiogenesis and vascular remodeling.
  • Focus on nuclear imaging modalities: Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT).

Main Results:

  • Various molecular imaging techniques have been developed to target key mediators in angiogenesis and vascular remodeling.
  • Nuclear imaging offers high sensitivity and specificity for detecting and quantifying molecular targets.

Conclusions:

  • Molecular imaging advances vascular biology research and offers clinical tools for early diagnosis, risk stratification, and therapeutic guidance.
  • Nuclear imaging techniques (PET, SPECT) demonstrate significant potential for clinical application in managing cardiovascular diseases related to vascular remodeling.

Keywords:
angiogenesisinflammationmatrix metalloproteinasemolecular imagingvascular endothelial growth factorvascular remodelingαvβ3 integrin

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