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Clinical Inquiry: Which nonhormonal treatments are effective for hot flashes?
Gary Kelsberg1, Leticia Maragh1, Sarah Safranek2
1University of Washington at Valley Family Medicine Residency, Renton, WA, USA.
Abstract:
Selective serotonin reuptake inhibitors (SSRIs [fluoxetine, sertraline, paroxetine]) and the selective norepinephrine reuptake inhibitor (SNRI) venlafaxine, as well as clonidine and gabapentin, reduce hot flashes by about 25% (approximately one per day) in women with and without a history of breast cancer. No studies compare medications against each other to determine a single best option.
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