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Dopamine transporter mutant animals: a translational perspective
Evgeniya V Efimova1,2, Raul R Gainetdinov1,2, Evgeny A Budygin1,3
1a Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg , Russia ;
Journal of Neurogenetics
|June 9, 2016
Summary
Altering the dopamine transporter (DAT) in mice reveals new insights into dopamine signaling and neuropsychiatric disorders. These studies offer novel therapeutic targets for treating dopamine-related conditions.
Area of Science:
- Neuroscience
- Pharmacology
- Genetics
Background:
- The dopamine transporter (DAT) regulates dopamine levels in the brain.
- Dysregulation of dopamine signaling is implicated in various neuropsychiatric disorders.
Purpose of the Study:
- To review recent research on genetically altered DAT function in animal models.
- To highlight translational studies offering insights into dopamine-related disorder pathology and pharmacology.
Main Methods:
- Utilizing genetically modified mouse models with altered DAT function.
- Focusing on translational studies connecting animal models to human conditions.
Main Results:
- Genetically altered DAT function provides insights into dopamine-mediated signaling.
- These models illuminate the pathology and pharmacology of dopamine-related disorders.
Conclusions:
- Animal models with modified DAT function are valuable tools for understanding neuropsychiatric disorders.
- These models offer potential for developing new therapeutic strategies targeting dopamine pathways.
