Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 3D-bioprinted head and neck cancer model for drug screening.

Biomedical materials (Bristol, England)·2026
Same author

Matrix Stiffness Directs Stemness Signatures in Breast Cancer.

Advanced healthcare materials·2026
Same author

Hydrogel microtumor arrays of patient melanoma recapitulate phenotypes and drug sensitivity.

Biomaterials advances·2026
Same author

Hierarchical stabilization of bioactive hydrogels by multi-arm peptide-polymer supramolecular staples.

Journal of materials chemistry. B·2026
Same author

Laser-Assisted Self-Monitoring of Blood Glucose: Analytical Performance, Clinical Accuracy, and Usability of the HandyRay-Glu System.

Diagnostics (Basel, Switzerland)·2026
Same author

Cyclic mechanical stretch suppresses intrinsic apoptosis in high metastatic melanoma.

Materials today. Bio·2026
Same journal

Electroactive Sodium Alginate-Based Hydrogel Textile for Synergistic Antibacterial and Regenerative Therapy in Diabetic Wound.

Advanced healthcare materials·2026
Same journal

Microfluidic Biofabrication of a Hydrogel Vessel-Like Structure for Interrogating Tumor Cell Propagation in a Breast Cancer-on-a-Chip Model.

Advanced healthcare materials·2026
Same journal

Hydrogel-Based Systems in Intrauterine Adhesions: Bridging the Gap from Bench to Bedside.

Advanced healthcare materials·2026
Same journal

A Muscle-Mimetic Core-Sheath Composite Yarn Scaffold for In-Body Tissue Induction and Regeneration of Small-Diameter Vascular Grafts.

Advanced healthcare materials·2026
Same journal

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden.

Advanced healthcare materials·2026
Same journal

Therapeutic Extracellular Vesicles from Synovial Fibroblast-Primed MSCs for Osteoarthritis Treatment.

Advanced healthcare materials·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
09:46

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

Published on: April 27, 2017

10.4K

Temporal Modulation of Stem Cell Activity Using Magnetoactive Hydrogels.

Amr A Abdeen1, Junmin Lee1, N Ashwin Bharadwaj2

  • 1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Advanced Healthcare Materials
|June 9, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed a magnetoactive hydrogel that allows reversible control over material stiffness using magnetic fields. This breakthrough enables dynamic manipulation of cell culture environments, impacting stem cell therapies and tissue engineering research.

Keywords:
biomedical applicationshydrogelsmagnetic materialsstimuli responsive materialstissue engineering

More Related Videos

Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment
08:10

Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment

Published on: June 10, 2025

688
Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
13:28

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

8.4K

Related Experiment Videos

Last Updated: Mar 19, 2026

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
09:46

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

Published on: April 27, 2017

10.4K
Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment
08:10

Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment

Published on: June 10, 2025

688
Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel
13:28

Gradient Strain Chip for Stimulating Cellular Behaviors in Cell-laden Hydrogel

Published on: August 8, 2017

8.4K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Cellular functions are regulated by dynamic extracellular matrix (ECM) mechanics.
  • Recreating in vivo ECM dynamics in vitro is challenging.
  • Current cell culture materials lack tunable mechanical properties.

Purpose of the Study:

  • To develop a novel magnetoactive hydrogel for tunable ECM mechanics.
  • To demonstrate reversible control of hydrogel elasticity using magnetic fields.
  • To validate the material's utility in modulating stem cell behavior.

Main Methods:

  • Fabrication of a magnetoactive hydrogel by embedding magnetic particles in a hydrogel matrix.
  • Modulation of hydrogel elasticity using external magnetic fields.
  • Assessment of mesenchymal stem cell (MSC) bioactivities, including proangiogenic factor secretion and osteogenesis.

Main Results:

  • Achieved orders of magnitude change in hydrogel elasticity with low magnetic fields.
  • Demonstrated reversible stiffening using permanent magnets.
  • Successfully controlled MSC proangiogenic molecule secretion and osteogenesis dynamically.

Conclusions:

  • Magnetoactive hydrogels offer a versatile platform for dynamic control of cell microenvironments.
  • This technology is applicable to various laboratory settings and therapeutic applications.
  • The ability to tune material properties reversibly supports advanced cell culture and regenerative medicine.