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Risk Factors for Severe Enteroviral Infections in Children

Somchai Owatanapanich, Rochana Wutthanarungsan, Wipaporn Jaksupa

    Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
    |June 10, 2016
    PubMed

    Insights

    Severe enterovirus infection in children with hand, foot, and mouth disease is linked to specific risk factors. Recognizing absence of oral lesions, seizures, and drowsiness is key for early intervention in pediatric patients.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Virology

    Background:

    • Hand, foot, and mouth disease (HFMD) is a common viral illness in children.
    • Enterovirus infections can lead to severe complications, particularly in pediatric populations.
    • Identifying risk factors for severe enterovirus infection is crucial for timely management.

    Purpose of the Study:

    • To investigate risk factors associated with severe enterovirus infection in hospitalized pediatric patients with HFMD.
    • To analyze clinical manifestations and pathogens involved in severe enterovirus cases.

    Main Methods:

    • Retrospective review of hospitalized pediatric patients (<15 years) with suspected enterovirus infection from 2011-2013.
    • Classification of cases into mild and severe enterovirus infection groups.
    • Univariate and multivariate logistic regression analysis to identify risk factors for severe infection.

    Main Results:

    • 156 patients analyzed; 16% (25) had severe enterovirus infection, with 5 deaths.
    • Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) were the major identified pathogens.
    • Absence of oral lesions, seizures, and drowsiness/lethargy were significant risk factors for severe infection.

    Conclusions:

    • EV71 and CA16 are primary causes of severe enterovirus disease in this cohort.
    • Absence of oral lesions, seizures, and drowsiness/lethargy are critical indicators for severe enterovirus infection.
    • Early identification and prompt treatment are vital to prevent disease progression in pediatric enterovirus infections.
    Abstract

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