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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

Postmortem serum levels of total IgE.

Lara Tran¹, Cristian Palmiere²

¹University Center of Legal Medicine, Chemin de la Vulliette 4, 1000, Lausanne 25, Switzerland.

International Journal of Legal Medicine

|June 10, 2016

Summary

Postmortem serum total IgE levels do not increase with postmortem intervals in non-allergic deaths. Severe trauma, sepsis, and cancer also do not systematically elevate IgE in postmortem samples.

Keywords:

Autopsy Death IgE Postmortem biochemistry

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Area of Science:

Forensic Pathology
Immunology
Toxicology

Background:

Total IgE (immunoglobulin E) levels in postmortem serum can be a potential indicator of atopic disposition or allergic reactions.
Understanding factors influencing postmortem IgE levels is crucial for accurate forensic and toxicological assessments.

Purpose of the Study:

To investigate if increasing postmortem intervals correlate with higher total IgE concentrations in non-allergic individuals.
To determine if traumatic deaths, sepsis, or systemic inflammation (e.g., disseminated malignancies) are associated with elevated postmortem serum IgE.

Main Methods:

Analysis of postmortem serum total IgE from femoral blood in four distinct non-atopic groups.
Groups included: increasing postmortem intervals, varying survival times post-trauma, sepsis, and disseminated malignancies.
Methods included unenhanced computed tomography, autopsy, histology, and biochemistry.

Main Results:

Increasing postmortem intervals did not show a progressive increase in postmortem serum IgE levels.
Severe trauma, bacterial sepsis, and disseminated malignancies were not systematically associated with increased postmortem serum IgE, regardless of survival time.

Conclusions:

Postmortem serum IgE levels are not reliably elevated by postmortem interval, trauma, sepsis, or malignancy.
The utility of postmortem total IgE for assessing atopy or acute allergic reactions remains uncertain, though measurement is feasible.