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Generation of ESC-derived Mouse Airway Epithelial Cells Using Decellularized Lung Scaffolds
Published on: May 5, 2016
Generation of Lung and Airway Epithelial Cells from Embryonic Stem Cells In Vitro
Sirous Sadeghian Chaleshtori1, Mohammad Reza Mokhber Dezfouli1, Mohammad Mehdi Dehghan2
1Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Abstract:
The epithelium covers the internal surface of the lung airways and is composed of numerous cell types that arise from the anterior foregut endoderm. The ability to generate pulmonary cells from embryonic stem cells will allow study of lung development, drug screening, regenerative medicine, and modeling of lung diseases. The aim of this review is to describe the methods used to produce lung cells in vitro, based on mechanisms of lung development in during embryology.
