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Human Mesenchymal Stem Cells in Cancer Therapy
Rasime Kalkan1, Nedime Serakinci2
1Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Turkish Republic of Northern Cyprus 99138.
Critical Reviews in Eukaryotic Gene Expression
|June 10, 2016
Summary
Human mesenchymal stem cells (hMSCs) show promise in cancer therapy and tissue regeneration. Their exosome-mediated abilities are key for therapeutic applications in oncology and regenerative medicine.
Area of Science:
- Biomedical Engineering
- Oncology
- Regenerative Medicine
Background:
- Human mesenchymal stem cells (hMSCs) possess multipotent differentiation capabilities.
- hMSCs are being explored for cancer therapy and as drug delivery systems.
- Exosomes and microvesicles derived from hMSCs play a role in tissue regeneration.
Purpose of the Study:
- To review the potential applications of hMSCs in cancer therapy.
- To highlight the role of hMSC-derived exosomes in tissue regeneration.
- To discuss hMSCs as therapeutic delivery vehicles.
Main Methods:
- Literature review of current research on hMSCs in cancer and regeneration.
- Analysis of studies focusing on hMSC-derived exosomes and microvesicles.
- Synthesis of findings regarding hMSC therapeutic potential.
Main Results:
- hMSCs demonstrate potential in modulating the tumor microenvironment.
- hMSC-derived exosomes exhibit significant tissue regeneration capabilities.
- hMSCs can be engineered as effective delivery vehicles for anti-cancer agents.
Conclusions:
- hMSCs offer a promising platform for novel cancer therapeutics.
- Exosome-mediated regeneration by hMSCs opens new avenues in regenerative medicine.
- Further research is warranted to fully elucidate and optimize hMSC-based therapies.
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