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Related Concept Videos

Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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Drug Development for Metastasis Prevention.

Yari Fontebasso1, Steven M Dubinett1

  • 1Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Critical Reviews in Oncogenesis
|June 10, 2016
PubMed
Summary
This summary is machine-generated.

Metastatic disease causes most cancer deaths, yet few drugs target it. This review explores molecular features, therapeutic targets, and strategies to overcome the drug development gap for better cancer treatment.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Development

Background:

  • Metastatic disease accounts for 90% of solid tumor deaths.
  • Effective therapeutic strategies for preventing and suppressing metastasis remain limited.
  • Few metastasis-specific molecular targets have been successfully translated into clinical treatments.

Purpose of the Study:

  • To review the current understanding of the molecular characteristics of metastatic disease.
  • To identify potential therapeutic targets within the metastatic cascade.
  • To analyze the reasons for the scarcity of anti-metastasis drugs and propose solutions.

Main Methods:

  • Literature review of current research on metastatic disease.
  • Analysis of molecular pathways involved in metastasis.
  • Discussion of preclinical and clinical drug development challenges.

Main Results:

  • Identified key molecular features and potential therapeutic targets in metastasis.
  • Highlighted the significant gap in anti-metastasis drugs within current cancer therapies.
  • Discussed factors contributing to the slow development of these drugs.

Conclusions:

  • Advancing the development of anti-metastasis drugs requires novel target discovery.
  • A deeper understanding of metastatic molecular biology is crucial.
  • Disruptive technologies and adapted preclinical/clinical settings can improve drug development success.