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Aqueous Two Phase System Assisted Self-Assembled PLGA Microparticles.

Nitish Yeredla1, Taisuke Kojima2,3, Yi Yang1

  • 1University of Michigan-Dearborn, Department of Mechanical Engineering, 4901 Evergreen Road, Dearborn, MI 48128, USA.

Scientific Reports
|June 10, 2016
PubMed
Summary
This summary is machine-generated.

We developed novel poly(lactide-co-glycolide) (PLGA) microparticles using an aqueous two-phase system (ATPS). These temperature-responsive particles offer tunable structures for advanced applications.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biotechnology

Background:

  • Poly(lactide-co-glycolide) (PLGA) is a widely used biodegradable polymer.
  • Developing microparticles with controlled morphology and responsive properties is crucial for advanced applications.
  • Aqueous two-phase systems (ATPS) offer unique environments for particle formation.

Purpose of the Study:

  • To create poly(lactide-co-glycolide) (PLGA) microparticles with diverse morphologies and temperature-responsive characteristics.
  • To investigate the self-assembly behavior of PLGA within a Pluronic F127/dextran ATPS.
  • To establish a novel platform for developing tunable micro/nano particles and polymersomes.

Main Methods:

  • Emulsification of PLGA in a Pluronic F127/dextran aqueous two-phase system (ATPS).
  • Guided self-assembly driven by ATPS to form microparticle structures.
  • Characterization of microparticle morphology (core-shell, composite) based on PLGA concentration.
  • Evaluation of temperature responsiveness due to Pluronic F127's lower critical solution temperature (LCST).

Main Results:

  • PLGA microparticles with varying morphologies (core-shell, composite) were successfully produced.
  • The microparticles demonstrated simultaneous incorporation of hydrophobic and hydrophilic molecules.
  • The particles exhibited temperature responsiveness owing to the Pluronic F127 component.
  • ATPS-guided self-assembly enabled tunable microparticle formation.

Conclusions:

  • A novel ATPS-assisted self-assembly method for creating PLGA microparticles was demonstrated.
  • The developed microparticles possess tunable structures and temperature-responsive properties.
  • This platform is suitable for creating advanced materials for theranostics, bioseparations, and complex particle synthesis.