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Updated: Jul 25, 2026

Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
The application of crystallization in the presence of additives to enable drug-in-capsule technology
Yildiz Yilmaz1,2, Faraj Atassi1, Manuel Sanchez-Felix1
1a Novartis Institutes for Biomedical Research , Cambridge , MA , USA.
Abstract:
Crystallization in the presence of additives such as surfactants, polymers or impurities has been widely investigated in the pharmaceutical and chemical industries in order to change the crystal habit or to obtain a more desirable polymorph, affect crystal growth and influence dissolution. However, in this study, we investigated the concept of crystallization in the presence of surfactants in order to incorporate into the crystal lattice, a small amount (less than 1% w/w) of surfactant, sodium lauryl sulfate (SLS). The resulting crystals were further compared to crystals coated with SLS using a washing procedure; in order to assess whether either procedure generates improvements in the apparent solubility and dissolution of a poorly soluble drug so it can be filled directly into a capsule without the need of a complex formulation process.
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