Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors.
Ruizhi Men1, Ning Li1, Chihong Ding2
1School of Traditional Chinese Materia Medica, Ministry of Education, Wenhua Road 103, Shenyang 110016, PR China; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, PR China.
Pharmacognosy Magazine
|June 10, 2016
Summary
Physalis minima fruits contain compounds with significant quinone reductase (QR) inducing activity. Isophysalin B and physordinose B show strong potential as chemopreventive agents, highlighting edible Physalis as a source of beneficial phytochemicals.
Area of Science:
- Phytochemistry
- Chemoprevention
- Pharmacognosy
Background:
- Physalis fruits are recognized for their culinary and functional food applications in Northeast China.
- Investigating the phytochemical basis of Physalis minima's health benefits is crucial.
Purpose of the Study:
- To identify and characterize bioactive compounds from Physalis minima.
- To evaluate the chemopreventive potential, specifically quinone reductase (QR) inducing activity, of its constituents.
Main Methods:
- Bioactivity-guided phytochemical isolation and structural elucidation using NMR and HRESIMS.
- Assay of quinone reductase (QR) inducing activity and detection of Michael reaction acceptors (MRAs).
Main Results:
- The ethyl acetate extract of Physalis minima L. (EEPM) exhibited notable QR inducing activity (IR 1.47 ± 0.24).
- Eight compounds were isolated, including isophysalin B (2) and physordinose B (6).
- Isophysalin B (IR 2.80 ± 0.19) and physordinose B (IR 2.38 ± 0.46) demonstrated significant QR inducing activity.
Conclusions:
- Isophysalin B and physordinose B are key compounds in Physalis minima responsible for potent QR induction.
- This research supports the utilization of edible Physalis fruits as a valuable source of chemopreventive phytochemicals.
Keywords:
GlutathioneMichael reaction acceptorsPhysalisPhysalis minimaquinone reductase inducing activityMore Related Videos
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