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Preparation and Evaluation of Andrographolide Solid Dispersion Vectored by Silicon Dioxide
Dingkun Zhang1, Junzhi Lin2, Fang Zhang1
1Department of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pharmacognosy Magazine
|June 10, 2016
Summary
Commercially available silica (SiO2) effectively enhances the dissolution of Andrographolide (Andro), an insoluble natural antibiotic. Solid dispersion using SiO2 offers a practical method to improve drug solubility and potential clinical efficacy.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Andrographolide (Andro) is a natural antibiotic with poor solubility, limiting its therapeutic use.
- Insoluble drugs present significant challenges in achieving effective bioavailability and clinical outcomes.
Purpose of the Study:
- To investigate the feasibility of using silica (SiO2) as a carrier for Andrographolide solid dispersion.
- To enhance the dissolution rate and bioavailability of Andrographolide.
Main Methods:
- Solid dispersions were prepared using the solvent evaporation method with varying process parameters.
- Characterization included particle size, surface area, pore volume, SEM, FTIR, and XRD analysis.
Main Results:
- Optimal solid dispersion preparation involved a 1:8 drug-to-carrier ratio (Andro:SiO2B) with tetrahydrofuran solvent at 50°C.
- The solid dispersion exhibited a unique structure, effectively dispersing Andrographolide and showing significantly improved dissolution compared to the crude drug and physical mixture.
Conclusions:
- Commercially available silica (SiO2) is a cost-effective and excellent carrier for improving Andrographolide dissolution.
- This approach offers a highly operable method for enhancing the dissolution of insoluble natural products, potentially improving clinical effects.
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