Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.8K
The Thyroid Gland01:23

The Thyroid Gland

8.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
8.4K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.4K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

201
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
201

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gestational weight gain and maternal immediate perinatal and postpartum outcomes in low and middle income countries: individual participant data meta-analyses.

BMJ medicine·2026
Same author

Association Between Serum Follicle-Stimulating Hormone Levels and Risk of Diabetes in Middle-Aged Men: A Long-Term Population-Based Longitudinal Study.

Endocrinology, diabetes & metabolism·2026
Same author

Coexistence of endometriosis and human papilloma virus: A systematic review and meta-analysis.

New microbes and new infections·2026
Same author

Thiostrepton potentiates chemotherapy-induced cell death in cisplatin-resistant SKOV3 cells.

BMC cancer·2026
Same author

Menopausal timing and its determinants among Iranian women: findings from the 2021 national STEPS survey.

Journal of diabetes and metabolic disorders·2026
Same authorSame journal

Polycystic Ovary Syndrome and Cardiometabolic Health Across Generation: Insights from 25 Years of the Tehran Lipid and Glucose Study (TLGS).

International journal of endocrinology and metabolism·2026

Related Experiment Video

Updated: Mar 19, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.4K

Thyroid and Pregnancy in Tehran, Iran: Objectives and Study Protocol.

Sima Nazarpour1, Fahimeh Ramezani Tehrani2, Masoumeh Simbar1

  • 1Department of Reproductive Health and Midwifery, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

International Journal of Endocrinology and Metabolism
|June 10, 2016
PubMed
Summary

This study investigated thyroid dysfunction in pregnant women in Tehran, finding levothyroxine treatment beneficial for those with thyroid autoimmunity, even without overt dysfunction. This aids in improving feto-maternal outcomes.

Keywords:
Clinical TrialPregnancyPregnancy StudyTehran ThyroidThyroid Dysfunction

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K
Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

824

Related Experiment Videos

Last Updated: Mar 19, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.4K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.6K
Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

824

Area of Science:

  • Endocrinology
  • Reproductive Health
  • Public Health

Background:

  • Thyroid dysfunction is common in women of reproductive age.
  • Data on subclinical thyroid issues impacting pregnancy outcomes are conflicting.
  • Thyroid autoimmunity prevalence and its impact on pregnancy require further investigation.

Purpose of the Study:

  • To determine the prevalence of thyroid dysfunction in pregnant women in Tehran.
  • To assess the effectiveness of levothyroxine treatment in pregnant women with thyroid autoimmunity.
  • To evaluate the impact of levothyroxine on feto-maternal outcomes in women with subclinical thyroid dysfunction.

Main Methods:

  • A two-phase study: cross-sectional screening and a double-blind randomized clinical trial.
  • Screening included TSH, T4, T-uptake, TPOAb, and urinary iodine levels in first-trimester pregnancies.
  • Participants with thyroid autoimmunity were randomized to receive levothyroxine (LT4) or no treatment, with outcomes monitored.

Main Results:

  • The study established the prevalence of thyroid dysfunction and iodine status in pregnant women in Tehran.
  • It provided data on the effects of levothyroxine treatment in women with subclinical thyroid dysfunction and thyroid autoimmunity.
  • The research aimed to clarify the benefits of LT4 in pregnant women without overt thyroid dysfunction.

Conclusions:

  • Levothyroxine treatment may improve pregnancy outcomes in women with thyroid autoimmunity.
  • Further research is needed to confirm the benefits of levothyroxine in subclinical thyroid dysfunction during pregnancy.
  • Universal thyroid screening in pregnancy is crucial for identifying at-risk populations.