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Postpartum domperidone use in British Columbia: a retrospective cohort study
Kate Smolina1, Steven G Morgan1, Gillian E Hanley1
1School of Population and Public Health (Smolina, Morgan); Department of Obstetrics and Gynaecology (Hanley); Child & Family Research Institute (Oberlander), University of British Columbia, Vancouver, BC; Faculty of Pharmacy and Charles Perkins Centre (Mintzes), University of Sydney, Australia.
Background:
Domperidone is commonly used off-label to stimulate milk production in mothers who have low milk supply. The aim of this study was to describe trends, patterns and determinants of postpartum domperidone use.
Methods:
This is a retrospective, population-based study involving all women with a live birth between Jan. 1, 2002, and Dec. 31, 2011, in the province of British Columbia. We examined administrative data sets containing person-specific information on filled prescriptions and use of medical services, and we used logistic regression to examine associations between domperidone use and maternal characteristics.
Results:
The study population consisted of 225 532 women with 320 351 live births. The prevalence of postpartum domperidone use more than doubled between 2002 and 2011. In 2011, 1 in 3 women with a preterm birth and 1 in 5 women with a full-term birth were prescribed domperidone in the first 6 months postpartum. Women who were older, had a higher body mass index, had a chronic disease, were first-time mothers, delivered more than 1 baby (multiple pregnancy), had a preterm birth or had a cesarian delivery were more likely to fill a postpartum domperidone prescription.
Interpretation:
We found an increase in postpartum domperidone use over a 10-year period. More research is needed on maternal and infant health outcomes.
