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Human neurobehavioral toxicology testing: current perspectives.

W K Anger1

  • 1Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226.

Toxicology and Industrial Health
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Standardized neurotoxicity tests are crucial for chemical safety. Current human neurobehavioral test batteries screen for effects but need broader assessments and normative data for reliable worksite evaluations.

Area of Science:

  • Environmental Health
  • Neuroscience
  • Toxicology

Background:

  • Standardized neurotoxicity testing is essential for premarket chemical assessment and building a comprehensive toxicity database.
  • Existing human neurobehavioral test batteries, developed by Finnish, WHO, and US researchers, screen for common neurotoxic effects.

Purpose of the Study:

  • To highlight the need for standardized neurotoxicity tests for regulatory purposes.
  • To review current human neurobehavioral test batteries and their limitations.
  • To discuss ongoing efforts to improve the reliability and validity of these assessments.

Main Methods:

  • Review of three prominent human neurobehavioral test batteries.
  • Identification of limitations in current test batteries, including sensory, motor, and affective function assessment.

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  • Discussion of challenges in field assessments, such as demographic and normative data gaps.

    • Main Results:

    • Current test batteries cover frequent neurotoxic effects but lack comprehensive sensory, motor, and affective assessments.
    • Worksite assessments are complicated by demographic differences and insufficient normative data.
    • National and international reliability and validity studies are underway for these test batteries.

    Conclusions:

    • Ongoing assessments aim to enhance the utility of human neurobehavioral test batteries.
    • Improving these tests will facilitate the development of a robust neurotoxicity database.
    • Standardized and validated tests are critical for accurate chemical safety evaluations.