Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hydrogen Bonds

Hydrogen Bonds

Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....

Hydrogen Bonds

Hydrogen Bonds

A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inhalation of hydrogen gas reduces exacerbations of acute aortic dissection in mice.

Life sciences·2026

Same author

Analysis of intracellular organelles in neurons differentiated from iPSCs of Chédiak-Higashi syndrome patients.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Same author

Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Molecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic mice.

The Journal of nutritional biochemistry·2025

Same author

A method for isolating and cryopreserving intact mitochondria with improved integrity and functionality.

Biophysics and physicobiology·2025

Same author

Cardiac dysfunction due to mitochondrial impairment assessed by human iPS cells caused by DNM1L mutations.

Pediatric research·2025

Search research articles

Related Experiment Video

Updated: Mar 19, 2026

New Application of an Atmospheric Pressure Plasma Jet as a Neuro-protective Agent Against Glucose Deprivation-induced Injury of SH-SY5Y Cells

New Application of an Atmospheric Pressure Plasma Jet as a Neuro-protective Agent Against Glucose Deprivation-induced Injury of SH-SY5Y Cells

Published on: October 9, 2017

Molecular Hydrogen as a Neuroprotective Agent.

Masumi Iketani, Ikuroh Ohsawa¹

¹Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.

Current Neuropharmacology

|June 10, 2016

Summary

Molecular hydrogen (H2) shows promise as an antioxidant and anti-inflammatory agent for neurological disorders. Research suggests H2 administration may help prevent, treat, and mitigate conditions like stroke and neurodegeneration.

More Related Videos

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Related Experiment Videos

Last Updated: Mar 19, 2026

New Application of an Atmospheric Pressure Plasma Jet as a Neuro-protective Agent Against Glucose Deprivation-induced Injury of SH-SY5Y Cells

New Application of an Atmospheric Pressure Plasma Jet as a Neuro-protective Agent Against Glucose Deprivation-induced Injury of SH-SY5Y Cells

Published on: October 9, 2017

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Area of Science:

Neuroscience
Biochemistry
Medical Research

Background:

Neurological disorders are often linked to oxidative stress and neuroinflammation.
Molecular hydrogen (H2) has emerged as a potential therapeutic agent with antioxidant and anti-inflammatory properties.

Purpose of the Study:

To review the progress of molecular hydrogen (H2) in treating neurological disorders.
To explore the potential mechanisms of H2 action in the brain.

Main Methods:

Literature review of animal models and human clinical studies on H2 administration.
Analysis of H2 administration routes: gas inhalation, dissolved water, and saline injection.
Discussion of H2's role in cerebrovascular, neurodegenerative, and neonatal brain disorders.

Main Results:

H2 administration via various routes has shown positive outcomes in preclinical and clinical studies.
H2 demonstrates potential in managing conditions such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain injuries.
Identified potential effectors include cell signaling molecules and hormones involved in combating oxidative stress and inflammation.

Conclusions:

Molecular hydrogen (H2) holds significant clinical potential for the prevention, treatment, and mitigation of neurological disorders.
Further research is necessary to elucidate the precise molecular targets of H2 action.