[Prevention of neurosensory hearing disorders in antibiotic-induced ototoxicosis]

On the basis of clinical and audiological examinations of 102 tuberculosis patients who were on a combined treatment which included aminoglycoside antibiotics (streptomycin and canamycin), neurosensory disorders of the hearing function were detected in 75% of them. A clinical trial of obsidan, a beta-blocking agent, was performed in which it was used as a protective drug against ototoxic antibiotics given to 112 patients. Its combined application with antibiotics of the aminoglycoside series decreased their toxic effect from 75.6% to 21.4%.