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Generalizing the Concept of Specific Compound Formulation Additives towards Non-Fluorescent Drugs: A Solubilization
Carmen Lawatscheck1, Marcus Pickhardt2, Sebastian Wieczorek1
1Humboldt-Universität zu Berlin, Department of Chemistry, Brook-Taylor-Strasse 2, 12489, Berlin, Germany.
Abstract:
Tailor-made compound formulation additives enable the testing of potential drugs with undesirable pharmacological profiles. A combinatorial approach using Raman microscopy as the readout method is presented to select peptide sequences from large one-bead-one-compound libraries. The resulting peptide-PEG conjugates solubilize potential prophylactic and therapeutic anti-Alzheimer compounds and can be used as specific additives not only for fluorescent but also for non-fluorescent compounds.
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