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Association between anxiety state and mitral valve disorders: A Taiwanese population-wide observational study

Navneet Kumar Dubey1, Shabbir Syed-Abdul2, Phung Anh Nguyen2

  • 1Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.

Computer Methods and Programs in Biomedicine
|June 11, 2016
PubMed
Abstract

Insights

Anxiety state (AS) and mitral valve disorders (MVD) show a strong association in Taiwan. This link is more pronounced in younger individuals and females, suggesting targeted screening and interventions.

Area of Science:

  • Cardiology
  • Psychiatry
  • Epidemiology

Background:

  • Limited understanding of the association between anxiety state (AS) and mitral valve disorders (MVD).
  • Current management strategies for comorbid AS and MVD lack consensus.
  • Need for epidemiological data on AS and MVD in the Taiwanese population.

Purpose of the Study:

  • To analyze the prevalence and association between AS and MVD in Taiwan.
  • To investigate age and gender differences in the AS-MVD association.

Main Methods:

  • Utilized Taiwan's National Health Insurance Research Database (NHIRD) from 2000-2002.
  • Employed phenome-wide association study (PWAS) portal for analysis.
  • Examined association strength across different age and gender demographics.

Main Results:

  • A significant overall association was found between AS and MVD.
  • The association was notably stronger in younger individuals (OR 15) compared to the elderly (OR 1.99).
  • Higher co-occurrence incidence observed in females, especially aged 40-49.

Conclusions:

  • Strong AS-MVD association necessitates MVD screening in all AS patients, particularly younger females.
  • Proposes integrated psychotherapeutic and pharmacologic interventions for comorbid AS and MVD.
  • Highlights the need for improved care for high-need Taiwanese patients with these comorbidities.
Keywords:
AnxietyComorbidityMitral valve disorders

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