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Updated: Mar 19, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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RVX-297- a novel BD2 selective inhibitor of BET bromodomains

Olesya A Kharenko1, Emily M Gesner1, Reena G Patel1

  • 1Zenith Epigenetics, Suite 300, 4820 Richard Road SW, Calgary, Alberta, T3E 6L1, Canada.

Biochemical and Biophysical Research Communications
|June 11, 2016
PubMed

Keywords:
BD1 and BD2 domainsBET inhibitorsBromodomainsCrystal structureRVX-297Selectivity

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