Resveratrol cocrystals with enhanced solubility and tabletability

Area of Science:

• Pharmaceutical Science
• Materials Science
• Crystallography

Background:

• Resveratrol (RES) is a polyphenol with potential health benefits but limited bioavailability.
• Developing novel formulations to improve RES solubility and delivery is crucial for therapeutic applications.

Purpose of the Study:

• To synthesize and characterize new resveratrol cocrystals with improved pharmaceutical properties.
• To evaluate the potential of these cocrystals for enhanced tablet formulation development.

Main Methods:

• Cocrystal synthesis using liquid-assisted grinding (LAG) and rapid solvent removal (RSR) with ethanol.
• Physicochemical characterization via PXRD, DSC, NMR, FT-IR, and HPLC.
• Evaluation of pharmaceutical properties: solubility, dissolution rate, tabletability, and hygroscopicity.

Main Results:

• Two new 1:1 cocrystals, RES-4ABZ and RES-ISN, were successfully synthesized.
• Both cocrystals exhibited significantly higher solubility and improved tabletability compared to pure resveratrol.
• The cocrystals demonstrated phase stability and were non-hygroscopic under high humidity.

Conclusions:

• The novel resveratrol cocrystals show enhanced solubility and tabletability, addressing key limitations of pure resveratrol.
• These RES cocrystals are promising candidates for developing advanced tablet formulations.
• The study highlights the utility of cocrystallization as a strategy for improving drug delivery and formulation characteristics.