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The genetics of exceptional longevity: Insights from centenarians
Alejandro Santos-Lozano1, Ana Santamarina2, Helios Pareja-Galeano3
1Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; GIDFYS, Department of Health Sciences, European University Miguel de Cervantes, Valladolid, Spain.
Abstract:
As the world population ages, so the prevalence increases of individuals aged 100 years or more, known as centenarians. Reaching this age has been described as exceptional longevity (EL) and is attributed to both genetic and environmental factors. Many genetic variations known to affect life expectancy exist in centenarians. This review of studies conducted on centenarians and supercentenarians (older than 110 years) updates knowledge of the impacts on longevity of the twenty most widely investigated single nucleotide polymorphisms (SNPs).
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