Related Experiment Video
Updated: Mar 19, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Steroid receptor RNA activator: Biologic function and role in disease
Chan Liu1, Hong-Tao Wu2, Neng Zhu3
1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China; Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China.
Steroid receptor RNA activator (SRA), a long noncoding RNA, coactivates nuclear receptors and influences biological and pathological processes. SRA shows promise as a prognostic marker for ER-positive breast cancer.
Area of Science:
- Molecular Biology
- Genetics
- Endocrinology
Background:
- Steroid receptor RNA activator (SRA) is a long noncoding RNA (lncRNA) with emerging roles in nuclear receptor (NR) coactivation.
- SRA acts as a scaffold and coactivator for various transcription factors, including androgen receptor (AR), estrogen receptors (ERα, ERβ), and others.
Purpose of the Study:
- To review the diverse roles of SRA in biological processes and diseases.
- To highlight SRA's involvement in tumorigenesis and its potential as a prognostic marker.
Main Methods:
- Literature review of studies on SRA function and its involvement in cellular pathways.
- Analysis of SRA's role in gene expression and its association with disease pathogenesis.
Main Results:
- SRA coactivates multiple nuclear receptors (AR, ERα, ERβ, PR, GR, THR, RAR).
- SRA is implicated in myogenesis, steroidogenesis, obesity, cardiomyopathy, and tumorigenesis.
- SRA-associated pathways (p38 MAPK, Notch, TNFα) are crucial in estrogen-dependent breast cancer.
Conclusions:
- SRA plays critical roles in both normal physiology and disease pathogenesis.
- SRA expression may serve as a prognostic biomarker in ER-positive breast cancer.
- Further research into SRA's molecular mechanisms is vital for developing targeted therapeutic strategies.
More Related Videos
10:51Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
09:07Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
Published on: June 21, 2016
Related Concept Videos
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Signal Transduction: Overview
Typically, signal transduction involves three...
Intracellular Hormone Receptors
Co-activators and Co-repressors
Co-activators and Co-repressors
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with...