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Updated: Mar 19, 2026
Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria
Xuan Chen1, Bin Wu1, Kalana W Jayawardana1
1Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
Abstract:
A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.
