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Updated: Mar 19, 2026
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Current and Emerging Therapies for Lupus Nephritis
Samir V Parikh1, Brad H Rovin2
1Division of Nephrology, Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Journal of the American Society of Nephrology : JASN
|June 11, 2016
Summary
Current lupus nephritis treatments improve survival but have high failure rates and toxicity. New therapies are needed to enhance long-term kidney outcomes and reduce side effects for lupus nephritis patients.
Area of Science:
- Nephrology
- Immunology
- Rheumatology
Background:
- Corticosteroids and cyclophosphamide improved survival for proliferative lupus nephritis, becoming standard care.
- Despite advances, treatment failures and progression to end-stage renal disease (ESRD) remain significant challenges.
- High treatment-related morbidity necessitates a shift towards therapies with improved renal outcomes and reduced toxicity.
Purpose of the Study:
- To review current therapeutic strategies for lupus nephritis.
- To summarize recent advances in understanding lupus nephritis pathogenesis.
- To describe emerging treatment approaches based on new mechanistic insights.
Main Methods:
- Literature review of current and emerging lupus nephritis treatments.
- Analysis of recent research on lupus nephritis pathogenesis.
- Discussion of clinical trials and novel drug development.
Main Results:
- Standard care (corticosteroids + immunosuppressants) has limitations in efficacy and safety.
- Numerous clinical trials of novel drugs have not yet surpassed the efficacy of the current standard of care.
- Understanding disease pathogenesis is driving the development of new therapeutic strategies.
Conclusions:
- Despite slow progress, research continues to seek improved lupus nephritis treatments.
- Emerging approaches based on enhancedpathogenesis understanding hold promise for better patient outcomes.
- The goal is to develop therapies superior to the current standard of care in both efficacy and safety.
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