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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Anticancer drugs during pregnancy.

Shingo Miyamoto1, Manabu Yamada2, Yasuyo Kasai2

  • 1Department of Medical Oncology, Japanese Red Cross Medical Center, Shibuya, Tokyo aaa17580@pop06.odn.ne.jp.

Japanese Journal of Clinical Oncology
|June 11, 2016
PubMed
Summary
This summary is machine-generated.

Cancer diagnoses in pregnancy are rising. This review examines safe chemotherapy timing, drug choices, and effects on mother and fetus, addressing concerns for women desiring children during treatment.

Keywords:
anticancer drugsmalformationpregnancy

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Area of Science:

  • Oncology
  • Maternal-Fetal Medicine
  • Pharmacology

Background:

  • Cancer diagnoses during pregnancy are increasing due to rising maternal age.
  • Evidence on chemotherapy administration during pregnancy is limited.
  • Managing cancer in pregnant patients presents unique challenges.

Purpose of the Study:

  • To review the effects of cytotoxic anticancer drugs and molecular targeted drugs on pregnant women and their fetuses.
  • To discuss appropriate chemotherapy timing and safe drug regimens.
  • To address issues for patients desiring to conceive during cancer treatment.

Main Methods:

  • Literature review of existing studies on chemotherapy in pregnancy.
  • Analysis of accumulated case data and research findings.
  • Synthesis of information on drug effects and patient management.

Main Results:

  • Emerging evidence guides appropriate chemotherapy timing and safe drug options.
  • Cytotoxic and molecular targeted drugs have varying effects on mother and fetus.
  • Challenges include novel drug impacts and fertility preservation.

Conclusions:

  • Careful consideration of drug safety, timing, and maternal-fetal effects is crucial.
  • Further research is needed on novel anticancer agents and fertility concerns.
  • Multidisciplinary management is essential for pregnant cancer patients.