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Related Concept Videos

Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

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Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
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Esophageal Strictures-I: Introduction01:30

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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
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Related Experiment Video

Updated: Mar 19, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
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Endoscopic radiofrequency ablation for malignant biliary strictures.

Fei Wang1, Quanpeng Li1, Xiuhua Zhang1

  • 1Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, P.R. China.

Experimental and Therapeutic Medicine
|June 11, 2016
PubMed
Summary

Endoscopic radiofrequency ablation (RFA) offers a safe and effective method for palliating malignant biliary strictures, significantly widening bile ducts. This novel therapy shows promising results for improving patient outcomes.

Keywords:
cholangiocarcinomaendoscopic retrograde cholangiopancreatographyendoscopymalignant biliary stricturesradiofrequency ablation

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Area of Science:

  • Gastroenterology
  • Interventional Endoscopy
  • Oncology

Background:

  • Malignant biliary strictures pose significant challenges in palliation.
  • Endoscopic radiofrequency ablation (RFA) is an emerging therapy, but its safety and feasibility require further definition.

Purpose of the Study:

  • To evaluate the feasibility and safety of endoscopic radiofrequency ablation (RFA) for treating malignant biliary strictures.

Main Methods:

  • Retrospective analysis of 12 patients undergoing 20 endoscopic RFA procedures for malignant biliary strictures.
  • Investigated adverse events, stricture diameters pre- and post-RFA, stent patency, and survival time.

Main Results:

  • All RFA procedures were technically successful. Mild adverse events (fever, pancreatitis) occurred in a small number of patients.
  • Significant increase in mean bile duct diameter from 5.3 mm to 12.6 mm (P≤0.001).
  • Median stent patency was 125 days; extrapolated median survival was 232 days.

Conclusions:

  • Endoscopic RFA is a feasible and safe palliative treatment for unresectable malignant biliary strictures.
  • RFA demonstrates efficacy in widening bile ducts and offers a potential survival benefit.