Web-based tools for microRNAs involved in human cancer

Area of Science:

• Molecular Biology
• Bioinformatics
• Oncology

Background:

• MicroRNAs (miRNAs) are small, non-coding RNAs regulating cellular processes.
• miRNAs function as oncogenes or tumor suppressors in cancer.
• They hold potential as diagnostic and prognostic biomarkers for various malignancies.

Purpose of the Study:

• To present a comprehensive review of online databases for microRNA cancer research.
• To categorize databases based on their focus (specific cancer types vs. multiple malignancies).
• To highlight resources for investigating miRNA mutations and target interactions.

Main Methods:

• Literature review and database curation.
• Identification and categorization of 14 relevant online databases.
• Analysis of database functionalities for miRNA cancer research.

Main Results:

• A curated list of 14 open-access online databases is presented.
• Databases cover diverse aspects of miRNA research, including specific cancers, pan-cancer analysis, mutations, and miRNA nomenclature.
• These resources are valuable for researchers, especially those with limited computational infrastructure.

Conclusions:

• Online databases are crucial tools for advancing microRNA cancer research.
• The reviewed databases offer accessible platforms for data mining and analysis.
• These resources facilitate the exploration of miRNAs as cancer biomarkers and therapeutic targets.