Related Experiment Video
Updated: Mar 19, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
Molecular epidemiology of human coxsackievirus A16 strains
Wenmin Yu1, Huanxin Xu2, Changchang Yin1
1The School of Basic Medical Science, Jiujiang University/Key Laboratory of Translational Medicine, Jiujiang, Jiangxi 332000, P.R. China.
Abstract:
The hand, foot and mouth disease (HFMD) epidemics have mainly been caused by human enterovirus 71 and human coxsackievirus A16 (CA16), which circulated alternatively or together in the epidemic area. The aim of the present study was to provide guidance in the prevention and control of HFMD from CA16 infection. The molecular epidemiology of the human CA16 strains was investigated. Overall, 1,151 specimens (throat swabs) were collected from 1,151 patients with HFMD symptoms. The results of the homology comparison in the VP1 of CA16 strains showed that the CA16 strains belonged to the B1b subgenotype. The difference of the 6 CA16 strains analyzed showed that the most prominent strain was the A genotype, and the most close strains were the B1 gene subtype, particularly the B1b gene subtype. With regards to the amino acids, in addition to the A genotype, the differences of amino acids with other gene subtype was not significant. The present data suggest that more effective and highly targeted intervention mechanisms could be developed for the prevention and control of HFMD.
Related Concept Videos
Viral Mutations
Viral Recombination
Arboviral Encephalitis
Investigation of Disease Outbreaks
Infectious Diseases and Their Occurrence
Cytomegalovirus Disease

