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Primary hepatic neuroendocrine tumor: A case report
Asahiro Morishita1, Hirohito Yoneyama1, Takako Nomura1
1Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Molecular and Clinical Oncology
|June 11, 2016
Summary
This case report details a rare primary hepatic neuroendocrine tumor (PHNET) in an elderly patient. The study highlights diagnostic challenges and successful transarterial chemoembolization treatment for liver metastases.
Area of Science:
- Hepatology
- Oncology
- Radiology
Background:
- Primary hepatic neuroendocrine tumors (PHNETs) are rare, and their occurrence in patients over 85 is exceptionally uncommon.
- Accurate diagnosis of intrahepatic liver tumors can be challenging due to overlapping imaging features with other malignancies.
Purpose of the Study:
- To report a rare case of primary hepatic neuroendocrine tumor (PHNET) in an 87-year-old patient.
- To describe the diagnostic workup and treatment of multiple intrahepatic metastases from PHNET.
Main Methods:
- Abdominal ultrasound, CT angiography, CT arterial portography, and contrast-enhanced MRI were utilized for tumor characterization.
- Positron emission tomography imaging was performed.
- Liver biopsy with immunohistochemical staining (cytokeratin AE1/AE3, synaptophysin, chromogranin A, CD56, hepatocyte antigen, CK7) and MIB-1 index assessment.
Main Results:
- Imaging revealed liver tumors with arterial enhancement and delayed washout, exhibiting specific contrast dynamics on MRI.
- Immunohistochemistry confirmed neuroendocrine markers and ruled out hepatocellular carcinoma.
- The patient was diagnosed with multiple intrahepatic metastases from a primary hepatic neuroendocrine tumor.
Conclusions:
- This is the first reported case of PHNET in a patient over 85 years old.
- Transarterial chemoembolization with miriplatin, gelatin sponge, and lipiodol was an effective treatment modality.
- The case underscores the importance of comprehensive diagnostic evaluation for rare liver tumors.
