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Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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Regorafenib could cause sinusoidal obstruction syndrome

Motoi Takahashi1, Shigeru Harada1, Hideo Suzuki1

  • 11 Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan ; 2 Department of Hepatology, 3 Department of Surgery, Steel Memorial Yawata Hospital, Kitakyushu, Japan.

Journal of Gastrointestinal Oncology
|June 11, 2016
PubMed
Summary

Regorafenib treatment for colon cancer may cause liver failure through sinusoidal obstruction syndrome (SOS). Early detection of lactate dehydrogenase increase can help identify this adverse effect.

Keywords:
Sinusoidal obstruction syndrome (SOS)acute liver failuredrug-induced liver injury

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