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Interplay between Reactive oxygen Species and MicroRNAs in Cancer

Jun He1, Bing-Hua Jiang1

  • 1Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, USA.

Current Pharmacology Reports
|June 11, 2016
PubMed

Insights

Reactive oxygen species (ROS) and microRNAs are key in cancer. This review explores their reciprocal relationship, revealing ROS-responsive microRNAs as potential cancer therapeutics targeting tumor progression and apoptosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Reactive oxygen species (ROS) production and microRNA expression are implicated in tumor development, progression, metastasis, and therapeutic response.
  • A reciprocal connection exists between ROS signaling and microRNA pathways, influencing cancer cell biology.
  • Understanding this crosstalk is crucial for cancer research and treatment strategies.

Purpose of the Study:

  • To review ROS-responsive microRNAs relevant to cancer.
  • To elucidate mechanisms by which ROS regulate microRNAs.
  • To highlight microRNAs that modulate cellular ROS homeostasis and their functions in tumorigenesis.

Main Methods:

  • Literature review of studies investigating ROS and microRNAs in cancer.
  • Analysis of mechanisms linking ROS signaling to microRNA regulation.
  • Identification of microRNAs affecting ROS homeostasis and their biological targets.

Main Results:

  • Several microRNAs are responsive to ROS and play roles in cancer.
  • ROS can regulate microRNA expression through various mechanisms.
  • Certain microRNAs can alter cellular ROS levels, impacting tumorigenesis.

Conclusions:

  • The interplay between ROS and microRNAs offers novel therapeutic avenues in oncology.
  • Targeting ROS-responsive microRNAs may provide strategies to combat ROS-mediated tumor progression.
  • Exploiting this relationship could lead to new approaches for inducing ROS-dependent apoptosis in cancer cells.

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