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Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
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  1. Home
  3. Correction: Experimental Treatment With Favipiravir For Ebola Virus Disease (the Jiki Trial): A Historically Controlled, Single-arm Proof-of-concept Trial In Guinea.
  1. Home
  3. Correction: Experimental Treatment With Favipiravir For Ebola Virus Disease (the Jiki Trial): A Historically Controlled, Single-arm Proof-of-concept Trial In Guinea.

Related Experiment Video

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

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Correction: Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically

    Plos Medicine
    |June 11, 2016

    View abstract on PubMed

    Summary
    This summary is machine-generated.

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    This study highlights the critical role of proper citation for scientific integrity and discoverability. Ensuring accurate digital object identifiers (DOIs) is essential for tracking research impact and preventing misinformation.

    Area of Science:

    • Scientific communication
    • Bibliometrics
    • Scholarly publishing

    Context:

    • Correction of a published article DOI is essential for academic integrity.
    • Accurate DOIs ensure proper citation and retrieval of scientific literature.

    Purpose:

    • To provide the correct Digital Object Identifier (DOI) for a specific publication.
    • To rectify an error in the article's metadata.

    Summary:

    • The article DOI 10.1371/journal.pmed.1001967 has been corrected.
    • This ensures the article is correctly identified and cited.

    Impact:

    • Improves the accuracy of scientific records.
    • Facilitates correct referencing and literature searches.