Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluation of three methods for determining initial vancomycin doses.

B H Ackerman1

  • 1Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205.

DICP : the Annals of Pharmacotherapy
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amoxicillin-clavulanic acid: additions and corrections.

Mayo Clinic proceedings·2000
Same author

Disposition of vessel dilator and long-acting natriuretic peptide in healthy humans after a one-hour infusion.

The Journal of pharmacology and experimental therapeutics·1997
Same author

Disturbances of taste and smell induced by drugs.

Pharmacotherapy·1997
Same author

The fluconazole era: management of hematogenously disseminated candidiasis in the nonneutropenic patient.

Pharmacotherapy·1997
Same author

In vitro testing of antibiotics.

Pharmacotherapy·1996
Same author

Intravenous ketorolac for pain management in a ventilator-dependent patient with thermal injury.

Pharmacotherapy·1996
Same journal

Eradication of methicillin-resistant Staphylococcus aureus vaginitis with mupirocin.

DICP : the annals of pharmacotherapy·1991
Same journal

Ketorolac formulary restriction and usage evaluation.

DICP : the annals of pharmacotherapy·1991
Same journal

Oral vancomycin-induced rash: case report and review of the literature.

DICP : the annals of pharmacotherapy·1991
Same journal

Imipenem/cilastatin drug utilization evaluation in a large community hospital.

DICP : the annals of pharmacotherapy·1991
Same journal

Pharmacist involvement in Society of Critical Care Medicine.

DICP : the annals of pharmacotherapy·1991
Same journal

Early anticoagulation therapy in deep vein thrombosis.

DICP : the annals of pharmacotherapy·1991
See all related articles

The Moellering nomogram with a six-hour interval best predicted initial vancomycin doses for patient simulations. However, early monitoring and dose adjustments are crucial for safe and effective vancomycin therapy.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Pharmacokinetics

Background:

  • Vancomycin is a critical antibiotic for treating serious Gram-positive infections.
  • Accurate initial dosing is essential to achieve therapeutic efficacy and minimize toxicity.
  • Existing dosing nomograms require evaluation for predicting optimal vancomycin serum concentrations.

Purpose of the Study:

  • To compare the predictive accuracy of three vancomycin dosing methods (Matzke, Moellering, Lake-Peterson) for initial dose selection.
  • To simulate steady-state vancomycin serum concentrations using a two-compartment open model.
  • To assess the ability of each method to achieve target vancomycin levels (1-hour postinfusion <30 µg/mL, trough >5 µg/mL).

Main Methods:

  • Utilized previously reported pharmacokinetic data from 25 patients.

Related Experiment Videos

  • Employed a two-compartment open pharmacokinetic model for simulations.
  • Calculated initial vancomycin doses based on Matzke, Moellering, and Lake-Peterson nomograms.

    • Main Results:

    • The Matzke method failed to achieve target levels in a significant percentage of simulations (48% for 1-hour, 88% for troughs).
    • The Moellering method successfully achieved target 1-hour levels in 96% and troughs in 72% (with 6-hour interval).
    • Lake-Peterson doses (8-10 mg/kg) showed higher rates of exceeding target 1-hour levels (28-40%) and failing to reach target troughs (20-28%).

    Conclusions:

    • The Moellering nomogram with a six-hour dosing interval demonstrated the highest success rate in simulations for initial vancomycin dosing.
    • Despite the Moellering method's superiority, vancomycin serum concentration monitoring remains essential.
    • Early monitoring and dose adjustments are necessary to ensure safe and effective vancomycin therapy, regardless of the initial dosing method used.