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Published on: January 18, 2019
Temporal Changes in Post-Infectious Glomerulonephritis in Japan (1976-2009)
Joichi Usui1, Takashi Tawara-Iida1, Kenji Takada2
1Department of Nephrology, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Post-infectious glomerulonephritis (PIGN) incidence in Japan peaked in the 1990s, driven by shifts in infectious diseases and an aging population. This study tracked PIGN trends over four decades, noting changes in causative agents and patient demographics.
Area of Science:
- Nephrology
- Epidemiology
- Infectious Diseases
Background:
- Global decline in post-infectious glomerulonephritis (PIGN) incidence over 50 years.
- Need to identify PIGN incidence trends in Japan over the past four decades.
Purpose of the Study:
- To analyze the frequency, clinicopathological findings, and prognosis of PIGN in Japan.
- To identify temporal trends in PIGN incidence and associated etiological agents.
Main Methods:
- Retrospective analysis of 6,369 PIGN cases from a Japanese Renal Biopsy Database (1976-2009).
- Histological diagnosis and evaluation of clinicopathological features and renal outcomes.
Main Results:
- PIGN incidence peaked in the 1990s, with shifts from post-streptococcal glomerulonephritis (PSGN) to Staphylococcus aureus infection-related nephritis (SARN) and hepatitis C virus-associated GN (HCVGN).
- Average age of onset increased from 33 to 51 years.
- SARN and HCVGN showed significantly higher renal death rates compared to other PIGN types.
Conclusions:
- PIGN incidence in Japan peaked in the 1990s, reflecting evolving infectious disease patterns and population aging.
- Increased susceptibility to infections in an aging population contributes to PIGN trends.
- SARN and HCVGN represent significant etiological shifts with poorer prognoses.
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