Films based on neutralized chitosan citrate as innovative composition for cosmetic application

Area of Science:

• Biomaterials Science
• Cosmetic Science
• Polymer Chemistry

Background:

• Chitosan, a biopolymer, is explored for its potential in developing biocompatible films.
• Neutralization of chitosan salts is crucial for creating stable and functional films.
• Citrate and acetate buffers are investigated as potential neutralizers.

Purpose of the Study:

• To evaluate citrate and acetate buffers as neutralizers for chitosan salts.
• To characterize chitosan films with and without glycerol for cosmetic applications.
• To assess the efficacy of neutralized chitosan citrate films in a skin model.

Main Methods:

• Preparation and characterization of neutralized chitosan citrate and acetate films.
• Analysis included thickness, moisture content, swelling, solubility, thermal analysis (STA), and differential scanning calorimetry (DSC).
• Evaluation of film performance in a skin model for hyaluronic acid release and cosmetic effects.

Main Results:

• Chitosan films neutralized with citrate buffer exhibited superior physical integrity, including greater thickness, lower moisture absorption, reduced solubility, and better swelling.
• Thermal analyses indicated a higher interaction with water in citrate-buffered films, beneficial for cosmetic use.
• Films prepared with chitosan citrate without glycerol demonstrated significant stratum corneum desquamation and hydration within 10 minutes on a skin model.

Conclusions:

• Neutralized chitosan citrate films possess enhanced physical integrity and water interaction, suitable for cosmetic applications.
• The chitosan citrate film without glycerol effectively promotes cosmetic skin exfoliation and hydration.
• These findings highlight the potential of chitosan citrate films as functional ingredients in cosmetic formulations.