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Updated: Mar 19, 2026

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
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Design of chitosan-based nanoparticles functionalized with gallic acid.

J Lamarra1, S Rivero1, A Pinotti2

  • 1Center for Research and Development in Food Cryotechnology (CCT-CONICET La Plata), 47 and 116, La Plata 1900, Argentina; Faculty of Exact Sciences, UNLP, Argentina.

Materials Science & Engineering. C, Materials for Biological Applications
|June 12, 2016
PubMed
Summary

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Corrigendum to "Valorization of a subutilized by-product of the yerba mate industry to design active packaging material based on gelatin,"[Int. J. Biol. Macromol. 335 (2026) 149098].

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Valorization of a subutilized by-product of the yerba mate industry to design active packaging material based on gelatin.

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Electrospun nanofibers of poly(vinyl alcohol) and chitosan-based emulsions functionalized with cabreuva essential oil.

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Nanocomposite bilayers based on poly(vinyl alcohol) and chitosan functionalized with gallic acid.

International journal of biological macromolecules·2019
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Assembly of chitosan support matrix with gallic acid-functionalized nanoparticles.

Materials science & engineering. C, Materials for biological applications·2017

Chitosan nanoparticles effectively deliver gallic acid (GA) for food, packaging, and pharmaceutical applications. Optimized formulations ensure high encapsulation efficiency and stability for advanced delivery systems.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biopolymers

Background:

  • Chitosan-based nanoparticles offer potential for controlled delivery of active compounds like gallic acid (GA).
  • Optimization of nanoparticle formulation is crucial for stability and encapsulation efficiency in various applications.

Purpose of the Study:

  • To optimize the design parameters of chitosan-gallic acid nanoparticles using Response Surface Methodology (RSM).
  • To evaluate the stability and encapsulation efficiency of the developed nanoparticles for potential applications.

Main Methods:

  • Nanoparticles were prepared via ionotropic gelation using chitosan (CH) and tripolyphosphate (TPP).
  • Response Surface Methodology (RSM) was employed to optimize CH concentration, CH:TPP ratio, and GA loading.
  • Zeta potential (ZP) and percentage encapsulation efficiency (PEE) were key parameters analyzed.
Keywords:
Central composite designIonotropic gelationPercentage encapsulation efficiencyQuickScanRSMZeta potential

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  • Stability was assessed using QuickScan, turbidity, ZP, transmittance, and nanoparticle diameter measurements.
  • Fourier Transform Infrared Spectroscopy (FTIR) was used to confirm interactions.

    • Main Results:

    • An optimal formulation (0.76% CH, 5:1 CH:TPP ratio, 37 mg GA/g CH) yielded +50mV ZP and 82% PEE.
    • Stable nanoparticle suspensions (ZP > +25mV, transmittance > 0.21, diameter ~140nm) were achieved with 0.5-0.75% CH and CH:TPP ratios > 3.
    • FTIR confirmed hydrogen bonding and ionic interactions between CH-TPP, facilitating GA encapsulation and stability.

    Conclusions:

    • Optimized chitosan-gallic acid nanoparticles demonstrate high encapsulation efficiency and stability.
    • These nanoparticles are suitable for modulated delivery in food, packaging, and pharmaceutical sectors.
    • The study provides a robust method for developing stable, functionalized nanoparticles.